Detaillierte Hinweise zur Behandlung von Opioidsucht
Detaillierte Hinweise zur Behandlung von Opioidsucht
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Because of the potential for serious adverse reactions hinein nursing infants from methadone, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
The use of methadone rein patients already known to have a prolonged QT interval has not been systematically studied.
This growth deficit does not appear to persist into later childhood. However, children born to women treated with methadone during pregnancy have been shown to demonstrate mild but persistent deficits rein performance on psychometric and behavioral tests.
Zidovudine – Experimental evidence demonstrated that methadone increased the area under the concentration-time curve (AUC) of zidovudine which could result rein toxic effects.
The total daily dose, potency and specific characteristics of the opioid the patient had been taking previously, if any;
The use of methadone has not been extensively evaluated rein patients with hepatic insufficiency. Methadone is metabolized rein the liver and patients with liver impairment may be at risk of accumulating methadone after multiple dosing.
Fertility – Reproductive function in human males may be decreased by methadone treatment. Reductions rein ejaculate volume and seminal vesicle and prostate secretions have been reported in methadone-treated individuals. Hinein addition, reductions rein serum testosterone levels and sperm motility, and abnormalities in sperm morphology have been reported. Published animal studies provide additional data indicating that methadone treatment of males can alter reproductive function.
Methadone oral tablet is a generic drug. It’s available as an oral soluble tablet under the Großfeuer name Methadose.
Extreme caution is necessary when any drug known to have the potential to prolong the QT interval is prescribed rein conjunction with methadone.
As with all opioids, administration of this product to the mother shortly before delivery may result in some degree of respiratory depression in the newborn, especially if higher doses are used. Methadone is not recommended for obstetric analgesia because its long duration of action increases the probability of respiratory depression hinein the newborn.
Renal Impairment – Methadone pharmacokinetics have not been extensively evaluated hinein patients with renal insufficiency. Unmetabolized methadone and its metabolites are excreted hinein urine to a variable degree. Methadone is a basic (pKa=9.2) compound and the pH of the urinary tract can alter its disposition rein plasma.
What are Methadone Hydrochloride Tablets? Methadone hydrochloride tablets are a prescription medicine that contains methadone, which is a narcotic pain medicine similar to morphine.
The respiratory depressant effects of opioids and their capacity to elevate cerebrospinal-fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase rein intracranial pressure.
Respiratory depression is the chief hazard Methadontabletten 10 mg online associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly rein the early dosing period.